Science Digest Newsletter - November 2025
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NOVEMBER 2025

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Cover_November_2025_1_SD

Identification of concepts of importance for the assessment of internal validity of in vitro toxicology studies using a modified Delphi technique

 

Journal
Evidence-Based Toxicology, Vol. 3 (2025), 1, 2551013.

 

Authors

Gro H. Mathisen, Camilla Svendsen, Gunn E. Vist, Trine Husøy, Heather M. Ames, Angela Bearth, Marc Audebert, Annette Bernhard, Anna Beronius, Ellen Bruzell, Emma Di Consiglio, Miles Davenport, Ingrid Druwe, Rene Geci, Ursula Gundert-Remy, Thomas Hartung, Sebastian Hoffmann, Helena Hogberg, Carlijn R. Hooijmans, Lucina Lizarraga, Jennifer Olker, Pilar Prieto, Joshua F. Robinson, Andrew A. Rooney, Adriano Sebollela, Nicola Smith, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Erin Yost, Amy Wang, Johanna Zilliacus, Paul Whaley

 

Work package
6

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Cover_November_2025_2_SD

AOP-networkFinder —
a versatile tool for the reconstruction and visualization of Adverse Outcome Pathway networks from AOP-Wiki

 

Journal
Bioinformatics Advances, Vol. 5 (2025), 1, vbaf007.

 

Authors
Nurettin Yarar, Marvin Martens, Torbjørn Rognes, Jan Lavender, Hubert Dirven, Karine Audouze, Marcin W Wojewodzic

 

Work package
7,5

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Cover_November_2025_3_SD

Endocrine disrupting toxicity of bisphenol A and its analogs: implications in the neuro-immune milieu

 

Journal
Journal of Xenobiotics, Vol. 15 (2025), 1, 13.

 

Authors
Erica Buoso, Mirco Masi, Roberta Valeria Limosani, Chiara Oliviero, Sabrina Saeed, Martina Iulini, Francesca Carlotta Passoni, Marco Racchim, Emanuela Corsini

 

Work package
5

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Cover_November_2025_4_SD

Adverse outcomes of the newly emerging bisphenol A substitutes

 

Journal
Chemosphere, Vol. 364 (2024), 143147.

 

Authors
Nina Franko, Anja Kodila, Marija Sollner Dolenc

 

Work package
5

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Cover_November_2025_5_SD

Evaluation of THP-1 and jurkat cell lines coculture for the in vitro assessment of the effects of immunosuppressive substances

 

Journal
Toxics, Vol. 12 (2024), 8, 607.

 

Authors
Nina Franko, Marija Sollner Dolenc

 

Work package
5

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Cover_November_2025_6_SD

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

 

Journal
Frontiers in Toxicology, Vol. 6 (2024), 1339104.

 

Authors

Igor Snapkow, Nicola M. Smith, Emma Arnesdotter, Karsten Beekmann, Etienne B. Blanc, Albert Braeuning, Emanuela Corsini, Marija Sollner Dolenc, Loes P. M. Duivenvoorde, Gunnar Sundstøl Eriksen, Nina Franko, Valentina Galbiati, Johanna M. Gostner, Nathalie Grova, Arno C. Gutleb, Rita Hargitai, Aafke W. F. Janssen, Solveig A. Krapf, Birgitte Lindeman, Katalin Lumniczky, Ambra Maddalon, Steen Mollerup, Lucia Parráková, Arkadiusz Pierzchalski, Raymond H. H. Pieters, Maria J. Silva, Anita Solhaug, Yvonne C. M. Staal, Anne Straumfors, Tünde Szatmári, Jonathan D. Turner, Rob J. Vandebriel, Ana Claudia Zenclussen, Robert Barouki

 

Work package
5

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Cover_November_2025_7_SD

A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans

 

Journal
Toxicological Sciences, Vol. 198 (2024), 2, 191–209.

 

Authors
Joost Westerhout, Annemiek den Heijer-Jordaan, Hans M G Princen, Rob Stierum

 

Work package
6

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Cover_November_2025_8_SD

Learning from Safe-by-Design for Safe-and-Sustainable-by-Design: Mapping the current landscape of Safe-by-Design reviews, case studies, and frameworks

 

Journal
Environment International, Vol. 183 (2024), 108305.

 

Authors
Akshat Sudheshwar, Christina Apel, Klaus Kümmerer, Zhanyun Wanga, Lya G. Soeteman-Hernandez, Eugenia Valsami-Jones, Claudia Som, Bernd Nowack

 

Work package
8

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More info on eu-parc.eu

List of work packages (WPs)

WP 1 Partnership management and coordination
WP 2 A common science-policy-agenda
WP 3 Synergies, collaborations and awareness
WP 4 Monitoring and exposure
WP 5 Hazard assessment

WP 6 Innovation in regulatory risk assessment
WP 7 FAIR data
WP 8 Concepts and toolboxes
WP 9 Building infrastructural and human capacities

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